Vitamin and mineral needs during the oral contraceptive therapy: a systematic review

Objectives: There is growing evidence that women using OCs change in serum trace elements and vitamins. Nowadays, in many cases, side effects associated with low levels of micronutrients are not considered during oral contraceptives (OCs) therapy. This review aims at checking the present literature in order to verify the evidences. Our purpose is to underline this aspect contributing to improve the therapeutic approach with OCs.Methods: Systematic literature search was performed in electronic databases, covering the period from January 1967 to January 2012.Results: Ninety-five articles were located; a cross sectional randomized and three RCTs studies were considered eligible.Conclusions: A decrease in the serum concentrations of zinc, selenium, phosphorus and magnesium have been reported in OC users. Such reductions were proportional to the duration of contraceptive use. These reductions may imply a reduction in the probability of having a pregnancy and/or an increase of serious illness for the unborn. In this regard, a supplementation with the above compounds could be useful in OC users, namely for reducing side effects

Acupressure on Self-Reported Sleep Quality During Pregnancy

The aim of this study was to investigate the short-term effect of acupression at the H7 point on sleep quality during pregnancy. After oral consent had been obtained, the midwife invited the women claiming to have poor sleep quality and anxiety symptoms to complete the Pittsburgh Sleep Quality Index questionnaire and the State-Trait Anxiety Inventory-1. Then, the same midwife, previously trained by an expert acupuncturist (I.N.), advised the women to put on the wrist overnight compression H7 Insomnia Control half an hour before going to bed and to take it off upon awakening, for 10 consecutive days and thereafter every odd day (active group). Women refusing to wear the device for low compliance toward acupression were considered as the control group. After 2 weeks, a second questionnaire evaluation was completed. In the active, but not in the control, group, a significant improvement of sleep quality was observed after H7 device application. The study suggests that H7 acupression applied for 2 weeks improves sleep quality in pregnant women. This preliminary result should serve to stimulate further studies on the long-term effects of acupression

Wireless Sensor Networks and Real-Time Locating Systems to Fight against Maritime Piracy

There is a wide range of military and civil applications where Wireless Sensor Networks (WSNs) and Multi-Agent Systems (MASs) can be used for providing context-awareness for troops and special corps. On the one hand, WSNs comprise an ideal technology to develop Real-Time Locating Systems (RTLSs) aimed at indoor environments, where existing global navigation satellite systems do not work properly. On the other hand, agent-based architectures allow building autonomous and robust systems that are capable of working on highly dynamic scenarios. This paper presents two piracy scenarios where the n-Core platform can be applied. n-Core is a hardware and software platform intended for developing and deploying easily and quickly a wide variety of WSNs applications based on the ZigBee standard. In the first scenario a RTLS is deployed to support boarding and rescue operations. In the second scenario a multi-agent system is proposed to detect the unloading of illegal traffic of merchandise at ports

The Role of Nuclear Receptors in the Pathophysiology, Natural Course, and Drug Treatment of NAFLD in Humans.

Nonalcoholic fatty liver disease (NAFLD) describes steatosis, nonalcoholic steatohepatitis with or without fibrosis, and hepatocellular carcinoma, namely the entire alcohol-like spectrum of liver disease though observed in the nonalcoholic, dysmetabolic, individual free of competing causes of liver disease. NAFLD, which is a major public health issue, exhibits intrahepatic triglyceride storage giving rise to lipotoxicity. Nuclear receptors (NRs) are transcriptional factors which, activated by ligands, are master regulators of metabolism and also have intricate connections with circadian control accounting for cyclical patterns in the metabolic fate of nutrients. Several transcription factors, such as peroxisome proliferator-activated receptors, liver X receptors, farnesoid X receptors, and their molecular cascades, finely regulate energetic fluxes and metabolic pathways. Dysregulation of such pathways is heavily implicated in those metabolic derangements characterizing insulin resistance and metabolic syndrome and in the histogenesis of progressive NAFLD forms. We review the role of selected NRs in NAFLD pathogenesis. Secondly, we analyze the role of NRs in the natural history of human NAFLD. Next, we discuss the results observed in humans following administration of drug agonists or antagonists of the NRs pathogenically involved in NAFLD. Finally, general principles of treatment and lines of research in human NAFLD are briefly examined

The Araucaria Project. The Distance to the Local Group Galaxy WLM from Near-Infrared Photometry of Cepheid Variables

We have obtained deep images in the near-infrared J and K filters for several fields in the Local Group galaxy WLM. We report intensity mean magnitudes for 31 Cepheids located in these fields which we previously discovered in a wide-field optical imaging survey of WLM. The data define tight period-luminosity relations in both near-infrared bands which we use to derive the total reddening of the Cepheids in WLM and the true distance modulus of the galaxy from a multiwavelength analysis of the reddened distance moduli in the VIJK bands. From this, we obtain the values E(B-V) = 0.082 $\pm$ 0.02, and $(m-M)_{0} = 24.924 \pm 0.042$ mag, with a systematic uncertainty in the distance of about $\pm$ 3%. This Cepheid distance agrees extremely well with the distance of WLM determined from the I-band TRGB method by ourselves and others. Most of the reddening of the Cepheids in WLM (0.06 mag) is produced inside the galaxy, demonstrating again the need for an accurate determination of the total reddening and/or the use of infrared photometry to derive Cepheid distances which are accurate to 3% or better, even for small irregular galaxies like WLM.Comment: latex, 6 figures. accepted to Ap

The Araucaria Project. An Accurate Distance to the Local Group Galaxy NGC 6822 from Near-Infrared Photometry of Cepheid Variables

We have measured near-infrared magnitudes in the J and K bands for 56 Cepheid variables in the Local Group galaxy NGC 6822 with well-determined periods and optical light curves in the V and I bands. Using the template light curve approach of Soszynski, Gieren and Pietrzynski, accurate mean magnitudes were obtained from these data which allowed us to determine with unprecedented accuracy the distance to NGC 6822 from a multi-wavelength period-luminosity solution in the VIJK bands. From our data, we obtain a distance to NGC 6822 of (m-M)_{0} = 23.312 +- 0.021 (random error) mag, with an additional systematic uncertainty of about 3 %. This distance value is tied to an assumed LMC distance modulus of 18.50. From our multiwavelength approach, we find for the total (average) reddening to the NGC 6822 Cepheids E(B-V) = 0.356 +- 0.013 mag, which is in excellent agreement with a previous determination of McGonegal et al. from near-infrared photometry and implies significant internal reddening of the Cepheids in NGC 6822. Our present, definitive distance determination of NGC 6822 from Cepheids agrees within 2 % with the previous distance we had derived from optical photometry alone, but has significantly reduced error bars. Our Cepheid distance to NGC 6822 is in excellent agreement with the recent independent determination of Cioni and Habing from the I-band magnitude of the tip of the red giant branch. It also agrees well, within the errors, with the early determination of McGonegal et al. (1983) from random-phase H-band photometry of nine Cepheids.Comment: Accepted to be published in the Ap

The Araucaria Project. Near-Infrared Photometry of Cepheid Variables in the Sculptor Galaxy NGC 55

We have obtained deep images in the near-infrared J and K filters of four fields in the Sculptor Group spiral galaxy NGC 55 with the ESO VLT and ISAAC camera. For 40 long-period Cepheid variables in these fields which were recently discovered by Pietrzy{\'n}ski et al., we have determined mean J and K magnitudes from observations at two epochs, and derived distance moduli from the observed PL relations in these bands. Using these values together with the previously measured distance moduli in the optical V and I bands, we have determined a total mean reddening of the NGC 55 Cepheids of E(B-V)=0.127 $\pm$ 0.019 mag, which is mostly produced inside NGC 55 itself. For the true distance modulus of the galaxy, our multiwavelength analysis yields a value of 26.434 $\pm$ 0.037 mag (random error), corresponding to a distance of 1.94 $\pm$ 0.03 Mpc. This value is tied to an adopted true LMC distance modulus of 18.50 mag. The systematic uncertainty of our derived Cepheid distance to NGC 55 (apart from the uncertainty on the adopted LMC distance) is $\pm$4%, with the main contribution likely to come from the effect of blending of some of the Cepheids with unresolved companion stars. The distance of NGC 55 derived from our multiwavelength Cepheid analysis agrees within the errors with the distance of NGC 300, strengthening the case for a physical association of these two Sculptor Group galaxies.Comment: latex. ApJ accepte

Fatty liver is associated with an increased risk of diabetes and cardiovascular disease-Evidence from three different disease models: NAFLD, HCV and HIV

Fatty liver, which frequently coexists with necroinflammatory and fibrotic changes, may occur in the setting of nonalcoholic fatty liver disease (NAFLD) and chronic infections due to either hepatitis C virus (HCV) or human immunodeficiency virus (HIV). These three pathologic conditions are associated with an increased prevalence and incidence of cardiovascular disease (CVD) and type 2 diabetes (T2D). In this multidisciplinary clinical review, we aim to discuss the ever-expanding wealth of clinical and epidemiological evidence supporting a key role of fatty liver in the development of T2D and CVD in patients with NAFLD and in those with HCV or HIV infections. For each of these three common diseases, the epidemiological features, pathophysiologic mechanisms and clinical implications of the presence of fatty liver in predicting the risk of incident T2D and CVD are examined in depth. Collectively, the data discussed in this updated review, which follows an innovative comparative approach, further reinforce the conclusion that the presence of fatty/inflamed/fibrotic liver might be a shared important determinant for the development of T2D and CVD in patients with NAFLD, HCV or HIV. This review may also open new avenues in the clinical and research arenas and paves the way for the planning of future, well-designed prospective and intervention studies